EFFECT OF NATURAL BIOENHANCERS ON SKIN PERMEATION: A JOURNEY FROM ORAL TO TOPICAL
The current focus of the researchers worldwide is to improve the health care therapies by reducing side effects and increasing the specific effects of the drug candidates. The current research work is a dig in this research area as novel concept of bioenhancers has been introduced for the skin permeation of drug candidates. The prime objective of the current research work was to explore the natural bioenhancers to increase the skin permeation. In this research work the amount of acyclovir permeation increases at the site of herpes virus simplex infection, using the natural compounds. In this work, cream of acyclovir prepared to study the effect of different concentration of three different natural bioenahncers quercetin, silibinin and luteolin. The distribution of the acyclovir in the skin was determined using different experimental protocols including in vitro skin permeation study which includes skin retention study, Ex-vivo skin permeation studies, HaCat cell lines study with MTT assay. The results of the above mentioned experimental studies showed that, the amount of acyclovir with the natural bioenhancers was approximately two folds than the plain acyclovir cream. This type of synthetic and natural therapy can improve acyclovir therapy for the patient.