Effect of natural bioenhancers on skin permeation: a journey from oral to topical

  • Karan Mittal The Maharaja Sayajirao Unoversity of Baroda


The current focus of the researchers worldwide is to improve the health care therapies by
reducing side effects and increasing the specific effects of the drug candidates. The current
research work is a dig in this research area as novel concept of bioenhancers has been introduced
for the skin permeation of drug candidates. The prime objective of the current research work was
to explore the natural bioenhancers to increase the skin permeation. In this research work the
amount of acyclovir permeation increases at the site of herpes virus simplex infection, using the
natural compounds. In this work, cream of acyclovir prepared to study the effect of different
concentration of three different natural bioenahncers quercetin, silibinin and luteolin. The
distribution of the acyclovir in the skin was determined using different experimental protocols
including in vitro skin permeation study which includes skin retention study, Ex-vivo skin
permeation studies, HaCat cell lines study with MTT assay. The results of the above mentioned
experimental studies showed that, the amount of acyclovir with the natural bioenhancers was
approximately two folds than the plain acyclovir cream. This type of synthetic and natural therapy
can improve acyclovir therapy for the patient.

Nov 30, 2017
How to Cite
MITTAL, Karan. Effect of natural bioenhancers on skin permeation: a journey from oral to topical. International Journal of Drug Research and Technology, [S.l.], v. 7, n. 7, p. 24, nov. 2017. ISSN 2277-1506. Available at: <http://ijdrt.com/index.php/drug-research-and-technology/article/view/144>. Date accessed: 19 jan. 2018.
Research Article