EFFECT OF A NEW SUPRAMOLECULAR HYDROGEL AGAINST CANDIDA ALBICANS BIOFILM

  • Douglas Lopes Cassimiro Universidade Estadual Paulista (Unesp)- Instituto de Quimica-Departamento de quimica analítica, Araraquara, Sao Paulo, Brazil
  • Wanessa de Cassia M. A. de Melo Faculdade de Ciencias Farmaceuticas da Universidade Estadual Paulista (Unesp)-Departamento de Analises Clínicas-Nucleo de proteomica, Araraquara, Sao Paulo, Brazil
  • Leonardo Miziara Barboza Ferreira Universidade Estadual Paulista (Unesp)- Instituto de Quimica-Departamento de quimica analítica, Araraquara, Sao Paulo, Brazil
  • Ana Marisa Fusco Almeida Faculdade de Ciencias Farmaceuticas da Universidade Estadual Paulista (Unesp)-Departamento de Analises Clinicas-Nycleo de proteomica, Araraquara, Sao Paulo, Brazil
  • Clovis Augusto Ribeiro Universidade Estadual Paulista (Unesp)- Instituto de Quimica-Departamento de quimica analitica, Araraquara, Sao Paulo, Brazil

Abstract

In recent decades, the incidence of fungal infections has considerable increased, particularly in immune compromised patients. Generally, opportunistic pathogens as Candida species are the main cause of invasive fungal infections, and are often associated with high morbidity and mortality. Candida albicans is a major fungal pathogen of humans, which present several virulence factors, especially the ability to form biofilm. The azoles are the mainly antifungal drugs used for the treatment of C. albicans infections. However, due to the presence of extracellular matrix, the C. albicans biofilm has significantly antifungal resistance, decreasing the efficacy of these conventional therapies. For these reasons, effective alternatives are required and increase the permeabilization of biofilm in order to antimicrobials reach deeper of this biofilm. So, in this study supramolecular polymer hydrogel was used as an alternative to increase the effectiveness of azoles. As results, the incubation (24 h) of mature C. albicans biofilms with the polymer (4%) associated with fluconazole (65 μg.mL-1) promoted ~ 70% inactivation of this fungus, while only the antifungal at same conditions inhibited ~ 40% of C. albicans. The control group (polymer 4%) it wasn’t capable to reduced fungi viability.

Published
Nov 30, 2017
How to Cite
CASSIMIRO, Douglas Lopes et al. EFFECT OF A NEW SUPRAMOLECULAR HYDROGEL AGAINST CANDIDA ALBICANS BIOFILM. International Journal of Drug Research and Technology, [S.l.], v. 7, n. 7, p. 22, nov. 2017. ISSN 2277-1506. Available at: <http://ijdrt.com/index.php/drug-research-and-technology/article/view/effect-of-a-new-supramolecular-hydrogel-against-candida-albicans-biofilm>. Date accessed: 16 july 2018.
Section
Short Communication