AN OVERVIEW ON DOCKING STUDIES WITH ALDOSE REDUCTASE INHIBITORS

  • Mohammed Zeyad Ahmmed Dahan Others, Sir Sayyed College Of Arts, Commerce And Science, INDIA
  • Sayyed Hussain Sajjansab Others, Sir Sayyed College Of Arts, Commerce And Science, INDIA
  • PK Zubaidha Department Of Chemical Sciences, Swami Ramanand Teerth Marathwada University, INDIA

Abstract

Molecular modeling methods have become integral part of drug discovery programs as they enable study of complex biological and chemical systems and hence design of lead molecules of therapeutic significance. Over the last few decades, it has been routinely and successfully applied in most pharmaceutical and biotech companies for a large number of applications. The activation of the key enzyme Aldose reductase in polyol pathway under hyperglycemic conditions is responsible for the development of late diabetic complications and it is an important drug target. This review provides an update on the docking strategies employed for screening various synthetic and natural aldose reductase inhibitors and provide an overview of the structural features involved in binding within the active site. The docking results reveal that several active constituents of medicinal plants exhibit remarkable aldose reductase activity and they may serve as lead for the development of novel ALRs of therapeutic significance.


Keywords

Aldose reductase, Polyol pathway, Inhibitors, Natural products, Docking studies, Review

Published
Feb 28, 2017
How to Cite
DAHAN , Mohammed Zeyad Ahmmed ; SAJJANSAB, Sayyed Hussain ; ZUBAIDHA, PK . AN OVERVIEW ON DOCKING STUDIES WITH ALDOSE REDUCTASE INHIBITORS. International Journal of Drug Research and Technology, [S.l.], v. 6, n. 5, p. 8, feb. 2017. ISSN 2277-1506. Available at: <http://ijdrt.com/index.php/drug-research-and-technology/article/view/an-overview-on-docking-studies-with-aldose-reductase-inhibitors>. Date accessed: 26 july 2017.
Section
Research Article