CURCUMIN, A PROMISING ANTI-CANCER THERAPEUTIC: ITíS BIOACTIVITY AND DEVELOPMENT OF DRUG DELIVERY VEHICLES

  • Subhankar Mandal Department Of Chemistry, University Of Kalyani, INDIA

Abstract

Curcumin, a natural polyphenol found in the dietary spice turmeric, has been demonstrated to inhibit cancer cell survival and proliferation, and to induce apoptosis without promoting the development of side effects. However, due to its sparing solubility and low bioavailability, curcumin has not yet been clinically used to treat cancer efficiently. This review describes the proposed bioactivity and mechanisms by which curcumin exhibits anti-cancer activity. Finally, I have reviewed the various approaches that have been studied to enhance the solubility and bioavailability of curcumin, including the preparation of co-crystals, and the development of delivery systems based on liposomes, micelles, exosomes, supramolecular gels and nanoparticles.


Keywords

Curcumin, Anticancer-bioactivity, Drug delivery systems, Liposome, Micelle, Nanoparticles, Hydrogels

Published
Feb 27, 2017
How to Cite
MANDAL, Subhankar . CURCUMIN, A PROMISING ANTI-CANCER THERAPEUTIC: ITS BIOACTIVITY AND DEVELOPMENT OF DRUG DELIVERY VEHICLES. International Journal of Drug Research and Technology, [S.l.], v. 6, n. 2, p. 14, feb. 2017. ISSN 2277-1506. Available at: <http://ijdrt.com/index.php/drug-research-and-technology/article/view/curcumin-a-promising-anticancer-therapeutic-its-bioactivity-and-development-of-drug-delivery-vehicles>. Date accessed: 16 nov. 2019.
Section
Research Article
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