SYNTHESIS, CHARACTERIZATION AND ANTIFUNGAL ACTIVITY OF VARIOUS SUBSTITUTEDQUINAZOLINONE DERIVATIVES CONTAINING AZETI/THIAZOLIDINONE MOIETY
Quinazolinones 4a-4h, 5a-5h have been synthesised by the cyclodensation of chloroacetyl chloride/ thioglycolic acid with N-N-arylidene derivatives (3a-3h) which in turn have been prepared by the action of substituted benzaldehyde on 3-amino-2-methyl-6-bromoquinazoline-4(3H)-one (2). The structures of the synthesized compounds have been confirmed by elemental analysis, IR and 1HNMR spectral data. All the products have been screened for their antifungal activity against several fungi such as A. fumigatus, C. albicans, C. albicans ATCC and C. krusei. The synthesized compounds were compared with standard drug fluconazole.