DESIGN AND EVALUATION OF SOLUBLE OCULAR DRUG INSERT FOR CONTROLLED RELEASE OF ACYCLOVIR
Acyclovir is an antiviral agent used in treatment of ocular infections. It is effective against human herpes viruses including herpes simplex virus type 1 and 2. It is available as a 3% w/w eye ointment to be applied 5 times a day in the eye. In the present work an ocular insert of acyclovir is prepared in order to minimize its side effects on being used as conventional dosage form in order to treat periocular disease like keratitis caused by virus. An attempt was made to formulate a soluble drug insert of acyclovir for its novel drug delivery containing natural hydrophilic polymer gelatin and sodium alginate while rate controlling membrane was prepared by hydrophobic ethyl cellulose using solvent casting method with the aim of increasing the contact time, achieving controlled release, reduction in frequency of administration, improving patient compliance and greater therapeutic efficacy. The formulated ocuserts were then evaluated for their average weight variation, thickness, drug content, in vitro drug release.