HEPATOPROTECTIVE ACTIVITY OF MUSSAENDA FRONDOSA LINN EXTRACT IN ETHANOL TREATED RATS
The present study was undertaken to investigate the protective effect and possible mechanism of alcoholic (AlE) and aqueous extract (AqE) from Mussaenda frondosa Linn (MF) on EtOH-induced hepatic injury in Wistar rat. Hepatotoxic parameters studied in vivo include serum transaminases (AST, and ALT), ALP, bilirubin, protein, lipid profile (Cholesterol, Triglyceride, VLDL and HDL) and level of antioxidants together with histopathological examination. Liv 52® was used as a reference hepatoprotective agent (5ml/kg-1b.w.). AlE and AqE (200 mg/kg-1b.w.) on oral administration decreased the level of AST, ALP, ALT, bilirubin, cholesterol, triglyceride, VLDL, MDA and increased the level of protein, HDL and antioxidants (SOD, GSH and CAT) in rats being treated with ethanol (EtOH). Histopathological observations confirmed the beneficial roles of MF against EtOH-induced liver injury in rats. Possible mechanism may involve their antioxidant activity.