FORMULATION AND EVALUATION OF ERYTHROMYCIN DENTAL IMPLANTS FOR PERIODONTITIS
Periodontitis is an inflammatory response to the overgrowth of anaerobic organisms in the subgingiva and if unchecked, results in the destruction of the bone and soft tissues supporting the tooth, which results in tooth loss. Erythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin. Erythromycin has antibacterial activity and is used in the treatment of superficial infections caused by organisms susceptible to Erythromycin. In present work dental implants were prepared by solvent casting technique using glass moulds. Implants were prepared by dissolving Ethyl cellulose alone and with copolymers (HPMC K4M, Sodium Alginate) in chloroform and dichloromethane (1:1) solution, using dibutyl phthalate and PEG‐400 as plasticizers. These formulated implants were then evaluated for different parameters like uniformity of thickness, uniformity of weight, tensile strength of the films, folding endurance and in vitro drug release.