FORMULATION AND EVALUATION OF ERYTHROMYCIN DENTAL IMPLANTS FOR PERIODONTITIS

  • Sudeep Kothari Division of Pharmaceutical Sciences, S.G.R.R.I.T.S. Patel Nagar
  • G Gnanaranjan Division of Pharmaceutical Sciences, S.G.R.R.I.T.S. Patel Nagar
  • Preeti Kothiyal Division of Pharmaceutical Sciences, S.G.R.R.I.T.S. Patel Nagar

Abstract

Periodontitis is an inflammatory response to the overgrowth of anaerobic organisms in the subgingiva and if unchecked, results in the destruction of the bone and soft tissues supporting the tooth, which results in tooth loss. Erythromycin is a macrolide antibiotic that has an antimicrobial spectrum similar to or slightly wider than that of penicillin. Erythromycin has antibacterial activity and is used in the treatment of superficial infections caused by organisms susceptible to Erythromycin. In present work dental implants were prepared by solvent casting technique using glass moulds. Implants were prepared by dissolving Ethyl cellulose alone and with copolymers (HPMC K4M, Sodium Alginate) in chloroform and dichloromethane (1:1) solution, using dibutyl phthalate and PEG‐400 as plasticizers. These formulated implants were then evaluated for different parameters like uniformity of thickness, uniformity of weight, tensile strength of the films, folding endurance and in vitro drug release.

Published
Apr 24, 2017
How to Cite
KOTHARI, Sudeep; GNANARANJAN, G; KOTHIYAL, Preeti. FORMULATION AND EVALUATION OF ERYTHROMYCIN DENTAL IMPLANTS FOR PERIODONTITIS. International Journal of Drug Research and Technology, [S.l.], v. 2, n. 5, p. 4, apr. 2017. ISSN 2277-1506. Available at: <http://ijdrt.com/index.php/drug-research-and-technology/article/view/96>. Date accessed: 28 feb. 2020.
Section
Research Article
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