A NOVEL SYNTHESIS OF SERIES OF INDAZOLE DERIVATIVE AS POTENT ANTIMICROBIAL AGENTS
A series of novel N-[(4-oxo-2-substituted aryl-1, 3-thiazolidine) –acetamidyl]-5-substituted indazoles (5a-p) were synthesized from N-(arylidene amino acetamidyl)-5-substituted indazoles (4a-p). The structures of these compounds were confirmed by IR, 1H NMR, MASS spectra and also micro-analytical data. The novel synthesized compounds were evaluated for their antimicrobial activity against variety of bacterial and fungal strains. The compounds 5l and 5m showed the maximum antimicrobial activity (MIC 11 and 12μg/ml) against Escherichia Coli and antifungal activity (MIC 9 and 10μg/ml) against A. flavus.
Indazole, 5-nitro Indazole, Thiazolidinone, Antimicrobial agents, Antifungal agents.