A NOVEL SYNTHESIS OF SERIES OF INDAZOLE DERIVATIVE AS POTENT ANTIMICROBIAL AGENTS

  • Chirag Parekh Department Of Pharmaceutical Chemistry, Sat Kaival College Of Pharmacy, INDIA
  • Aashini Modi Department Of Pharmaceutical Chemistry, Sat Kaival College Of Pharmacy, INDIA
  • Jagath Pillai Department Of Pharmaceutical Chemistry, Sat Kaival College Of Pharmacy, INDIA
  • Bhagirath Patel Department Of Pharmaceutical Chemistry, Sat Kaival College Of Pharmacy, INDIA

Abstract

A series of novel N-[(4-oxo-2-substituted aryl-1, 3-thiazolidine) –acetamidyl]-5-substituted indazoles (5a-p) were synthesized from N-(arylidene amino acetamidyl)-5-substituted indazoles (4a-p). The structures of these compounds were confirmed by IR, 1H NMR, MASS spectra and also micro-analytical data. The novel synthesized compounds were evaluated for their antimicrobial activity against variety of bacterial and fungal strains. The compounds 5l and 5m showed the maximum antimicrobial activity (MIC 11 and 12μg/ml) against Escherichia Coli and antifungal activity (MIC 9 and 10μg/ml) against A. flavus.


Keywords

Indazole, 5-nitro Indazole, Thiazolidinone, Antimicrobial agents, Antifungal agents.

Published
Feb 28, 2017
How to Cite
PAREKH, Chirag et al. A NOVEL SYNTHESIS OF SERIES OF INDAZOLE DERIVATIVE AS POTENT ANTIMICROBIAL AGENTS. International Journal of Drug Research and Technology, [S.l.], v. 2, n. 3, p. 9, feb. 2017. ISSN 2277-1506. Available at: <http://ijdrt.com/index.php/drug-research-and-technology/article/view/a-novel-synthesis-of-series-of-indazole-derivative-as-potent-antimicrobial-agents>. Date accessed: 15 sep. 2019.
Section
Research Article
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