DESIGN, SYNTHESIS AND CHARACTERIZATION OF NOVEL MOLECULES COMPRISING BENZOTHIAZOLE AND SULPHONAMIDE LINKED TO SUBSTITUTED ARYL GROUP VIA AZO LINK AS POTENT ANTIMICROBIAL AGENTS
The benzothiazole, sulphonamide and azo moieties are crucial functionalities because of their wide variety of biological activity and have wide range of therapeutic properties. Keeping in view the importance of these organic moieties, some new compounds were synthesized which contains benzothiazole, sulphonamide with azo moieties in the same molecule. As a part of systematic investigation of synthesis and biological active series of compounds N-(substituted 1, 3-benzothiazol-2-yl)-4-(substituted aryl diazenyl) benzenesulphonamide from substituted 2-amino benzothiazole have been synthesized. The Structures of all the synthesized compounds were elucidated on the basis of Physical characterization (Melting point, TLC) and different Spectroscopy techniques (IR, 1H NMR and Mass spectroscopy). All the synthesized compounds are evaluated for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and antifungal activity against Candida albicans and compared with standard drugs by agar disk diffusion method. The minimum inhibitory concentration (MIC) was also determined by the broth microdilution technique. The synthesized target compounds showed significant antibacterial and antifungal activity against the microbial strains used.
Benzothiazole, Sulphonamide, Azo moiety, Antibacterial activity, Antifungal activity.