International Journal of Drug Research and Technology

DESIGN AND DEVELOPMENT OF AYURVEDIC ANTHELMINTIC COLON TARGETING TABLET OF ISOPELLETIERINE

Abstract

Bhoyate Vinod B, Tarkase KN and Suruse SD

Small intestine is mostly the site for drug absorption but in same case the drugs need to be targeted to colon due to some factors like local colonic disease degradation related conditions, delayed release of drugs, systemic delivery of protein and peptide drugs etc. Colon targeted drug delivery is important and relatively new concept for the absorption of drugs because it offers almost neutral pH and long residence time. For the successful targeting of drugs to colon the dosage form should be designed such that it prevents the drug delivery in upper GIT and release it in colonic region. Plants had been used for medicinal purposes long before recorded history. In the last few decades there has been an exponential growth in the field of herbal medicine. It is getting popularized in developing and developed countries owing to its natural origin and lesser side effects. Researchers are being carried out now days on a large scale to discover the herbal alternatives for various allopathic medicines. Anthelmintic drugs are one such example for which herbal alternatives are being searched. In this research we confirmed the anthelmintic activity of Pomegranate (Punica granatum). Like pomegranate, other drugs, mainly garlic, quassia, barberry are also studied upon for their anthelmintic activity.