+447897072958FORMULATION DEVELOPMENT, OPTIMIZATION AND EVALUATION OF BILAYER PUSH-PULL OSMOTIC PUMP TABLET OF ATENOLOL USING 32 FACTORIAL DESIGNS
Abstract
Kailas N Tarkase and Pooja V Kadu
The objective of this study was to Formulate, Optimize and Evaluate Bilayer Push Pull Osmotic Pump Tablet of Atenolol Using 32 Factorial Designs. The main aim is to improve the site specification and to provide the controlled release of drug for once-a-day drug delivery system. The push pull osmotic tablets were prepared by double compression method; this study evaluates that regardless of the drug properties which do not significantly affect the drug delivery, the release kinetics is mainly controlled by some factors as, the plasticizer proportion in the membrane, the osmotic agent proportion and the drug layer polymer grade. The influence of each factor was investigated defining their acceptability range. Results, shows that the use of suspension agent in drug layer affects the drug release. The formulation batch F3 was taken as ideal optimized batch. On the basis of results the effect of orifice diameter, polymer concentration in drug layer, coating composition and plasticizer amount was tested and promising results were found. The drug release was independent of pH but dependent on the osmotic pressure of the dissolution medium. The release kinetics followed the peppas model.
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