International Journal of Drug Research and Technology

MICROBIOLOGICAL PROFILE OF URINARY TRACT INFECTION IN PEDIATRIC AGE, EGYPTIAN TWO CENTERS EXPERIENCE

Abstract

Mohamed Abdelaziz El-Gamasy, Mostafa M. Mehrez, Ahmed Ragab Fakhreldin and Abul-Fotouh Eid Alenany

Background: Urinary tract infection (UTI) is the most common nosocomial infection among hospitalized patients. Area specific monitoring studies aimed to gain knowledge about the type of pathogen responsible for UTIs and their resistance patterns may help the clinician to choose the correct empirical treatment. We aimed to study the type of urinary pathogens isolated from hospitalized patients with 1st episode UTI in our locality and its antibiotic susceptibility pattern.

Patient and method: Urine samples were collected from 320 clinically suspected cases of urinary tract infection from inpatient wards and outpatient clinic of Pediatric Nephrology unit of Pediatric Departments of Tanta University Hospital and Aswan University Hospital during the period from June 2016 to June 2017. The samples were tested microbiologically by standard procedures. Antibiotic susceptibility of the isolated pathogens was tested for commonly-used antibiotics by disc diffusion method according to hospital policy.

Results: Significant bacteruria was present in 75% of the samples, 16.25% were sterile and 8.75% showed insignificant bacteruria. The most common pathogen were E. coli (55%), Klebsiella spp. (26.6%) and Proteus mirabilis (14.2%). The mean susceptibility was high for Amikacin (85%), Ceftriaxone (82%), Cefotaxime (80%), Nitrofurantoin (80%), and Nalidixic acid (78%) but low for Ampicillin (21%), Cephalaxin (30%), and Sulphamethoxazol + Trimethoprim (37%).

Conclusion: The antibiotics commonly used in UTIs like trimethoprim / sulphamethoxazole, ampicillin and cephalexin does not seem to be appropriate for the empirical treatment of community-acquired UTIs because of their very high rate of resistance., regular monitoring is required to establish reliable information about resistance pattern of urinary pathogens for optimal empirical therapy of patients with UTIs.