International Journal of Drug Research and Technology

RP-HPLC METHOD FOR THE ESTIMATION OF ACECLOFENAC IN TABLET DOSAGE FORM

Abstract

Jat R.K.1*,R. C. Chhipa 1, S. Sharma 2

A simple, sensitive and precise RP

-

HPLC method was developed for the determination of

aceclofenac

in

tablet dosage form. The RP

-

HPLC separation was achieved on hypersil C18 column (250 mm, 4.6 mm,

5μm) using mobile phase

water:

acetonitrile (55:45

v/v) at flow rate of 1 ml/min at ambient temperature.

Quantification

was achieved with photodi

ode array detection at 277 nm over

the concentration range of 1

-

10

μm/ml. The method was validated statistically and applied successfully for the determination o

f

acecl

ofenac