International Journal of Drug Research and Technology

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF NEW INDOLYLCOUMARIN DERIVATIVES CONTAINING THIAZOLIDINONE MOIETY

Abstract

Indu Singh, Arun Kumar

As a part of systematic investigation of synthesis and biological activity, several new 2-(2-substituted- 5- ethoxy/methoxy-1H-indol-3-yl)-3-(2-oxo-2H-chromen-3-yl) thiazolidin-4-ones (4a-4h) have been synthesi zed by the reaction of 3-(2-substituted-5-ethoxy/methoxy-1H-indol-3-yl) methyleneamino)-2H-chromen-2- ones (3a-3h) with thioglycolic acid in presence of anhydrous zinc chloride. All the synthesized products are evaluated for their antibacterial activity against S. aureus, E. coli and K. pneumoneae and antifungal activity against C. albicans, C. albicans ATCC and C. krusai and compared with reference drugs gattifloxacin and fluconazole respectively. Compounds 4g and 4h showed more potent antibacterial and antifungal activity. The structures of the newly synthesized compounds have been characterized by elemental, spectral (IR, 1HNMR and Mass) analysis and the purity of these compounds has been checked by TLC method.